Cardi B is pulling no punches when it comes to ICE ... telling fans they’d better be ready to throw down if agents pop up at her shows.

The rapper didn't mince words Wednesday during the opening night of her "Little Miss Drama Tour" in Palm Desert, California. At one point, she climbed onto an elevated platform while singing “La Cucaracha" ... then scanned the crowd and asked if there were any Guatemalans or Mexicans in the audience.

Moments later, she fired off her warning ... "Bitch, If ICE comes in here, we gon’ jump they asses,” drawing booming cheers from the crowd.

She kept it going, joking ... "I’ve got some bear mace in the back! They ain’t taking my fans, b*tch,” before launching into her hit song, "I Like It."

Over the weekend, Cardi also praised Bad Bunny for speaking out against ICE, saying she’s proud to see Latinos standing in solidarity. You'll recall ... Bad Bunny said “ICE out” while accepting an award at the Grammys -- sparking backlash from conservatives, including President Donald Trump.

No mystery where Cardi stands -- we reached out to DHS ... so far, no word back.