Geriatrician Lolita Nidadavolu discusses the latest research on circulating cell-free DNA and its relationship to frailty. Past research has shown that older adults with higher levels of cell-free DNA have faster rates of developing frailty and memory impairment. Dr. Nidadavolu and researchers with the Johns Hopkins Biology of Healthy Aging Program found that characterizing cell-free DNA tissue of origin can identify individuals who are more likely to develop frailty and who have higher rates of cardiovascular comorbidity. Published in the Journals of Gerontology, these findings offer insights into developing biochemical methods to characterize frailty subtypes, with the eventual goal of identifying personalized interventions for frailty that use cell-free DNA tissue of origin. #cellfreedna #johnshopkins #healthyaging