Savannah Guthrie is “leaning on” her family members amid her mom Nancy Guthrie’s disappearance.

Pima County Sheriff Chris Nanos shared with Us Weekly on Monday that the 84-year-old’s absence has been “tough on” the “Today” show anchor, 54, and her siblings, sister Annie Guthrie and brother Camron Guthrie.

“They’re leaning on each other,” Nanos said. “They’re very cooperative with us and everything we’re doing.”

He went on to call Savannah and her loved ones “involved and engaged,” adding, “It is tough, there’s no doubt.”

The official noted that Annie was the last person to see Nancy after bringing her back to her house from dinner Saturday night.

The matriarch was reported missing when she didn’t show up to church Sunday morning — and cops reportedly found blood and signs of forced entry at her residence.

Nanos said in a press conference Monday that she may have been “taken from the home against her will, possibly in the middle of the night.”

He believes Nancy was abducted, explaining, “This is an elderly woman in her mid-80s who suffers from ailments. … She couldn’t go 50 yards.”

She, notably, is “sharp as a tack” and of “sound mind” — but urgently needs her medication.

Savannah has been absent from the “Today” show while navigating the crisis and is set to pull out of hosting the Winter Olympics later this week.

The journalist released an initial statement Monday, reading, “On behalf of our family, I want to thank everyone for the thoughts, prayers and messages of support. Right now, our focus remains on the safe return of our dear mom.

“We thank law enforcement for their hard work on this case and encourage anyone with information to contact the Pima County Sheriff’s Department at 520-351-4900,” the former attorney added.

Later that same evening, Savannah urged her Instagram followers to “please pray.”

She wrote, in part, “Thank you for lifting your prayers with ours. … Raise your prayers with us and believe with us that she will be lifted by them in this very moment.”

The Daytime Emmy winner’s dad, Charles Guthrie, died of a heart attack when Savannah was a teenager.