Johns Hopkins allergy and immunology specialist Antoine Azar discusses the role of primary immunodeficiency syndromes for the otolaryngologist as they relate to recurrent infections, chronic sinus disease and immune-mediated hearing loss. Primary immunodeficiency disorders cause weak immune systems and can be diagnosed in adults and children alike. The most common forms are antibody deficiency disorders, which manifest as recurrent, unusual or severe infection, most commonly in the respiratory tract. In the video, Azar advises otolaryngology professionals to recognize and screen for primary immunodeficiency syndromes, and to assess the response to vaccines. He also suggests treatment options.