Emergency responders are working to put out flames in northeast Philadelphia after a small plane crashed down on Friday evening ... leaving a chaotic aftermath and a number of suspected casualties.

It's currently unclear what caused the crash, which took place just after 6 PM near Cottman Avenue and Roosevelt Boulevard in the region ... but police have shared that 2 people were onboard the aircraft when it plummeted down.

The status of the passengers is unknown at this time.

Still, multiple casualties have been reported in the aftermath of the plane crash ... with several others injured, given the plane reportedly hit cars and businesses during the crash.

Video footage of the wreck shows the explosive aftermath and how it lit up the night sky before erupting into a massive smoke plume.

The crash in Philadelphia comes 2 days after another plane-related tragedy ... where an American Eagle regional jet flying from Wichita, Kansas and an Army helicopter collided above the Potomac River, not far from the Ronald Reagan Washington National Airport in D.C.

President Trump confirmed on Thursday that the D.C. collision left no survivors ... over 40 out of 67 bodies have been recovered in the days since.

This story is developing...